Composition:

Each 1 gm contains:

Doxycycline hyclate             865.6 mg

(Equal to doxycycline base    750 mg)

Properties:

Doxycycline is a broad spectrum antibiotic with bacteriostatic action.

It is active against Many of Gram +ve & Gram-ve bacteria, certain Mycoplasma, Chlamydia, Rickettsia and Protozoa. It is not effective against Viruses, Yeasts and Fungi, Like other tetracycline antibiotics.

Doxycycline inhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome,

As a result,It prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex.

The in-vitro activity of doxycycline against germs that cause respiratory infections in the

Pig is much more pronounced than other classic tetracyclines.

There is complete cross-resistance with other antibiotics of the tetracycline group.

Broilers:

Colibacillosis caused by E-coil.

CRD caused by Mycoplasma gallisepticum.

Broiler chickens:

20 gm of product /1000 kg.b.wt. in drinking water for 3/5 days(1 gm/5 liter).

Warnings and precautions:

The tetracyclines are primarily bacteriostatic substances. Concomitant use with-

Bactericidal antibiotics (penicillins, Cephalosporins, trimethoprim) may possibly

Cause antagonistic effect.

The bivalent and trivalent cations can form complexes with doxycycline.

Withdrawal:

Meat (pigs): 5 days.

Meat (Broiler chickens): 10 days.

Storage condition:

In temperature not exceed 30C in dry place, and used immediately after opening & reconstitution.

Packing:

500 gm.