Composition: Each 1 ml contains:

Ivermectin…5 mg
Closantel sodium dihydrate……….135.9 mg    (Equivalent to closantel 125 mg)

Properties:
Hepaclosan is a combination of ivermectin and closantel formulated as a solution for injection
used for cattle and sheep. The product is effective against a wide range of internal and external
parasites.
Ivermectin is an avermectin macrocyclic lactone and acts by inhibiting nerve impulses. It
enhances the release of gamma-aminobutyric acid (GABA) at presynaptic neurons. GABA acts
as an inhibitory neurotransmitter which blocks the post-synaptic stimulation of neuron in
nematodes or muscle fibers in arthropods resulting in paralysis of the parasite and eventual
death.
Closantel is a parasiticide with flukicide activity and efficacy against certain other helminths and
arthropods. Closantel is a member of the salicylanilide group of anthelmintics. It acts by
uncoupling oxidative phosphorylation.

Indications:

Hepaclosan is indicated for the treatment of the following:

• Gastrointestinal roundworms: Ostertagia ostertagi (including inhibited larval stages),Ostertagia lyrata (adult), Haemonchus placei (adult and immature), Trichostrongylus axei (adult and immature), Trichostrongylus colubriformis (adult and immature),Cooperia oncophora (adult and immature), Cooperia punctata (adult and immature),Cooperia pectinata (adult and immature).
• Toxocara vitulorum (adult), Trichuris spp.
• Lungworms: Dictyocaulus viviparus (adult and 4th stage larvae).
• Liver Fluke (trematodes): Fasciola gigantica, Fasciola hepática.
• Eyeworms (adult): Thelazia spp.
• Nasal Bots: Oestrus ovis.
• Mange Mites: Psoroptes ovis.

Dosage:
1 ml Hepaclosan per 25 kg B.Wt.

Withdrawal periods :
Cattle:
Meat: 49 days.
Sheep:
Meat: 28 days.
Not to be used in cattle or sheep producing milk for human consumption including pregnant
animals intended to produce milk for human consumption.

Packs:
50 ml.